As a gal with sensitive skin and a body that continues to remind me I am not 20 anymore, I was thrilled to come across Timeline Longevity, a brand that is backed by 80 patents, over 15 years of research, and impressive results from 25 human clinical trials. This is a brand that checks many of my (very critical) boxes.
The real kicker with Timeline is that they are focused on longevity at the cellular level, specifically the health of our mitochondria. In the world of human longevity and healthspan science, the mitochondria are taking center stage and are a new access point for the everyday consumer.
Mark my words: The mitochondria will be getting the same hype as fibermaxxing and cortisol regulation within the next six months.
And well deserved! As you may know from high school biology (or from reading rileypearce.ca over the years), the mitochondria are the powerhouses of our cells, generating the energy our cells need to perform their everyday functions.
What makes mitochondria even more interesting and intricately linked to our longevity is the fact that every type of cell has a specialized version of the mitochondria to ensure the right type of energy is delivered (with the exception of red blood cells).
This is part of the reason why monitoring their health status and supporting their natural recycling and regenerating processes is crucial to the long-term health of our brain, lungs, cardiovascular system, and especially our musculoskeletal system.
Our teens and 20s were years when we focused on big-picture health outcomes that we could see or feel. But preserving that vitality well into our 30s and beyond requires a completely different approach and level of understanding.
I want to keep nerding out on mitochondria with you, but first, I’d like to introduce you to Timeline Longevity and explain why I’m so eager to test their skincare line and their longevity gummies over the next few weeks.
Who is Timeline Longevity?
Timeline Longevity, previously known as Amazentis, is a Swiss-born company with rich roots in research and longevity science. The company started in 2007 as a spin-off from the Swiss Federal Institute of Technology in Lausanne, Switzerland, spearheaded by Chris Rinsch and Patrick Aebischer.
If you want to know how credible these guys are, Chris Rinsch holds the following educational degrees:
- An MBA from INSEAD, France
- A PhD in Cell and Molecular Biology from the University of Lausanne
- A Master of Science in Biomedical Engineering from U.T. Southwestern Medical Center
- A Bachelor of Science in Engineering from Harvey Mudd College
Patrick Aebischer is equally impressive. His resume includes:
- Trained as an MD (1980) and a Neuroscientist (1983) at the Universities of Geneva and Fribourg
- Faculty member at Brown University, USA (1984 to 1992), University of Lausanne (1992 to 2000), and EPFL (2000 to 2019)
- President of EPFL from 2000 to 2016
- Founder of four biotech companies: CytoTherapeutics, Modex, Amazentis (Timeline), and Vandria
Safe to say, these guys know what they are talking about, and they are passionate about Urolithin A and longevity science. When brilliant minds collaborate, the resulting innovations are usually market-defining.
Their dedication to developing well-researched, innovative, and science-backed products has even caught the attention of the mega-legacy brand, L’Oréal. Now, however you feel about L’Oréal is fair, but in this context, to be recognized by a brand that has been serving the beauty and anti-aging needs of consumers for over 50 years means you are doing something remarkable. This is especially true when you’re not a brand that necessarily caters to the viral trends of Gen Alpha and Gen Z.
The attention Timeline has received isn’t about hype or views on TikTok; it’s about having a high-quality product with clinical effectiveness. I have mentioned many times on my website that excellence – and the brands and people who exemplify excellence within their industry – will always get my attention.
Timeline is clearly dedicated to that standard. With their patented Mitopure™ and Mito-Biotic™ technologies, they are here to change how we think about aging on a cellular level.
Product Line-Up
Timeline currently offers two lines of products: their Mitopure™ supplement, available in either a gummy, softgel capsule, or drinkable form, and their new skincare line, which delivers the science of Mitopure™ directly to the skin.
Here are the specific product details:
| Product | Purpose | CAD | USD |
| Mitopure™ Gummies | Targets signs of aging at the source, increases cellular energy, strengthens muscle | $140 | $99 |
| Mitopure™ Softgels | The simplest form of Mitopure for cellular energy and muscle strength | $140 | $99 |
| Mito-Biotic™ Gentle Cleanser | Purifies and prepares the skin while supporting the barrier | $78 | $55 |
| Mito-Biotic™ Firming Serum | Delivers concentrated Mitopure for a tighter, lifted appearance | $282 | $200 |
| Mito-Biotic™ Resurfacing Exfoliator | Renews skin texture and boosts radiance gently | $99 | $70 |
| Mito-Biotic™ Dewy Cream | Deeply hydrates and promotes a youthful, glowing complexion | $226 | $200 |
| Mito-Biotic™ Eye Cream | Targets fine lines and fatigue around the delicate eye area | $162 | $115 |
| Mito-Biotic™ Barrier Cream | Locks in moisture and fortifies the skin’s natural defenses | $282 | $200 |
So what exactly is Mitopure™, and why are the mitochondria considered the next great frontier of longevity science?
The Mitochondria’s Role in Healthy Ageing
Let me be perfectly clear – aging is a beautiful and natural process. One of my absolute favourite quotes is:
“Longevity isn’t about adding years to our life; it’s about adding life to our years.”
With that said, I am a big advocate for finding strategies that delay the physical and metabolic impacts of aging, such as the loss of bone density, decreased mobility, increased risk of illness, and the inevitable slowing of our metabolism. These factors can drastically impact our quality of life as we age. Therefore, efforts like regular exercise, quality sleep, and a balanced diet in our 20s through 50s will make our 60s through 90s (and beyond!) much more capable and enjoyable.
This brings me back to the mitochondria and visionary companies like Timeline, who are offering scientifically validated ways to restore optimal mitochondrial function.
It is widely understood in the scientific community that the mitochondria, and the myriad processes they support, directly impact how quickly the body ages on a cellular level. Take good care of your mitochondria, and they’ll give you a long, healthy, energetic life. Neglect them, and you risk accelerating their decline and accelerating the cellular side of aging.
This is why I feel so passionate about helping women get moving and demystifying the noisy fitness industry. I want you to feel empowered to make informed decisions so that you’re confident that the efforts you make today will pay off later. Step one, as supported by studies and clinical trials, is to get your body moving every day. Your mitochondria supply the energy to your muscles and your brain, so if you take care of both through regular exercise, you’re already ahead of the game.
The next step is understanding what you can do from a nutritional perspective to support your mitochondria when you’re not exercising. Enter: Urolithin A.
Urolithin A is the Key to Unlock Long-Term Mitochondrial Health
If you’ve been reading my blog for a while, you know that I will always emphasize that supplements are meant to supplement your diet, not replace a solid nutritional foundation. Whether I am testing lines from IM8, Youth & Earth, or Organika, I apply the same strict standard. I will always make sure you know how to source a specific vitamin or mineral from whole foods before recommending a bottled alternative.
So, what about Urolithin A? Can we simply get this from our diet and save ourselves the CAD $140 / USD $99, and why should we even consider it in the first place?
Natural Forms of Urolithin A
Yes, you can sort of get Urolithin A from food, but it is unfortunately not that simple. Urolithins are a family of compounds that are produced by specific gut microbiota when they digest foods like pomegranates, walnuts, and almonds. These foods are rich in complex polyphenols called ellagitannins.
Here is the catch: only about 30% to 40% of the population possesses the right type of gut bacteria (specifically strains like Proteobacteria, Clostridium, Bifidobacterium, Eubacterium, and Enterococcus faecium) to successfully perform this conversion.
Even if you eat a bunch of walnuts and pomegranates every day, your body might not be producing any Urolithin A if your microbiome lacks these specific bugs. This biological bottleneck leads us directly to the conversation around supplementing Urolithin A, and specifically, Timeline’s patented Mitopure™.
The Deep Science: Autophagy, Mitophagy, and Glutathione
To truly understand the power of Timeline’s formulation, we need to look into the clinical research surrounding how Urolithin A functions within the human body. One finding that is of particular relevance here is that Urolithin A activates a signaling pathway (PINK1/Parkin) that is involved in mitochondrial quality control.
Through this pathway, Urolithin A promotes the selective aggregation, degradation, and removal of damaged, dysfunctional mitochondria. This targeted cellular cleanup process is known as mitophagy.
“Mitophagy is a process of selective removal of damaged or unnecessary mitochondria using autophagic machinery”
Think of it like taking out the microscopic trash; if you let damaged mitochondria accumulate in your cells, they create oxidative stress and severely drag down your cellular efficiency over time.
So Urolithin A is there to help keep our mitochondria is peak form, while removing waste on a regular schedule.
The next place where research has found Urolithin A to influence mitochondrial health is in the expression of glutathione S-transferases (GST, for short).
If you read my recent article on glutathione, you already know how crucial glutathione is to the body! As a quick reminder: GSTs are important antioxidant enzymes that are deeply tied to our overall antioxidant capacity. Urolithin A stimulates the signaling pathway that increases the expression of these GSTs. This increases autophagy (natural cell clean-up) and further supports the mitochondrial quality control mentioned above.
In summary: Urolithin not only helps keep the mitochondria in check, but also supports the processes that keep all cells in check through a system of antioxidant enzymes.
And the good times just keep on rolling, because not only does Urolithin A support mitophagy and broad autophagy, but it also supports the process that activates AMPK.
A quick break to apologize for all of the biology acronyms. Like the names in a fantasy novel, it’s okay to skim past the acronyms to get to the real meat of the sentence.
Why do we care about this? Well activation of AMPK promotes fatty acid oxidation and improves insulin sensitivity, both important processes in managing inflammation and blood-sugar levels. Simultaneously, AMPK is reducing fatty acid synthesis (meaning fewer fat cells are created) and suppresses something called gluconeogenesis (which results in less circulating sugar and fewer insulin spikes).
For anyone following a ketogenic eating style or incorporating intermittent fasting into their schedule, keeping insulin levels steady and promoting efficient fatty acid oxidation is the pinnacle of metabolic flexibility.
Supplementing with a compound that naturally supports these exact pathways is a game-changer.
Extending Cellular Health to the Skin
We have covered what Urolithin A does for our muscles and cells, but Timeline has recently launched a skincare line to address the mitochondrial decline in our largest organ – our skin.
Just as our muscles need a lot of energy to recover from exercise, our skin cells also require energy to regenerate, produce fresh collagen, and repair the inevitable daily damage caused by UV exposure, pollution, and harsh weather.
Timeline’s Mito-Biotic™ skincare range is formulated to apply the mitochondrial science of Mitopure™ to the skin.
The Timeline Skincare Routine
- The Mito-Biotic™ Gentle Cleanser purifies the skin without stripping away the lipid moisture barrier. It’s important to prep the skin gently and properly so that the active ingredients in the next steps can penetrate effectively.
- Following a gentle cleanse, the Mito-Biotic™ Resurfacing Exfoliator encourages cellular turnover. We know that as we age, our skin’s natural shedding process slows down, which can lead to a dull complexion. Urolithin A + gentle exfoliation = shedding to reveal an energized, refreshed complexion.
- Next up is a true heavy lifter in this routine: the Mito-Biotic™ Firming Serum. In any solid skincare routine, serums are usually where you find the highest, most potent concentration of active ingredients. This serum is specifically designed to deliver a concentrated dose of Mitopure™ right where the skin needs it most. This step stimulates localized, cellular-level energy renewal for a visibly tighter, firmer, and glowy appearance over time.
- The final step is up to you! The moisture and active ingredients from the previous steps can be securely locked in with either the Mito-Biotic™ Dewy Cream or the Mito-Biotic™ Barrier Cream.
- The Dewy Cream offers deep, luxurious hydration that promotes a youthful, glowing complexion
- The Barrier Cream is a slightly thicker option specifically formulated for protecting the skin’s natural defenses. If you have ever experienced skin distress from travel or climate changes. A great option if you’re going to be on a plane, or facing the cold, dry air of a Canadian Winter.
- The Mito-Biotic™ Eye Cream is a bonus step for folks looking to target the delicate skin around the eyes. This cream addresses early fine lines and visible signs of fatigue.
My Timeline Testing Protocol
In a supplement and skincare market overflowing with grandiose claims and viral TikTok trends, it is really refreshing to see a brand anchored in actual, peer-reviewed clinical data. They do not just rely on theoretical pathways; they have the receipts!
Their commitment to transparency, which is evident in their detailed educational blogs and easily accessible scientific literature, builds a deep sense of trust.
For me, optimizing health is entirely about stacking positive, sustainable habits over time. It’s the consistency in strength training, the targeted, whole-food nutrition, the structured fasting windows, and the meticulous attention to wearable recovery metrics.
Incorporating a product like Mitopure™ feels like the ultimate missing puzzle piece for localized, cellular-level maintenance. Because the gummies are sugar-free, they perfectly align with my ketogenic preferences, ensuring I can support my mitochondria without inadvertently spiking my blood sugar or breaking a fast.
I will be testing the full Timeline Longevity skincare suite alongside the gummies over the upcoming weeks, keeping an eye on things like fine lines on my face and my recovery metrics on my Garmin and Ultrahuman Ring Air.
Aging may be an inevitable privilege, but the rate at which our individual cells decline does not have to be out of our control.
Stay tuned for my full, detailed review right here on rileypearce.ca once I have put these products through their paces.
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