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IM8 has quickly become my go-to supplement brand for my daily essentials because they’re well-researched, tested, and I have noticed positive changes in my well-being since starting their Daily Ultimate Essentials back in early March of this year (2025).
Since then, the company has grown in popularity, completed their first clinical trial with amazing results, with participants experiencing 95% increase in energy and 85% improvement in feeling of bloat and/or digestive upset.
So when I heard that they were reformulating their longevity supplement, I knew that they were going to be cooking up something to not only complement the daily essentials, but that it would be a leader in its category.
In this article, I want to take you through the new IM8 Daily Ultimate Longevity supplement, the ingredients that make this supplement special, and whether I think it is worth the investment.
A Brief Introduction to Longevity Science
Before talking about the supplement that is designed to support longevity, let’s clear up what longevity really means.
The scientific study of longevity is one of the most interesting fields of human research. We are all bound to age. It is the most natural process and cycle, but being the curious creatures that we are – we’ve been trying to decode this cycle to determine what we can do to live a longer, healthier life.
You may be familiar with the famous study from Harvard which is the longest longevity study, tracking 238 Harvard students from the 1920s to the present day, and has followed their children and grandchildren, expanding the study to over 1300 participants. Their major conclusion is that our social lives and the quality of our interpersonal relationships are key indicators of how long we will live.
At a deeper level, longevity research has looked into things like our diet, with many scientists promoting fasting as a way to secure a longer lifespan. Nobel Prize winning scientists researched how telomeres, which are like caps on the end of our DNA strands, gone deeper, studying our DNA, can be indicators of longevity or shorter lifestpans.
It’s safe to say that we are obsessed with looking for the proverbial “Fountain of Youth” and from this obsession, we’ve seen some incredible science and research on display. From the research, we’ve uncovered several compounds that are showing promising results in how they interact with the internal systems controlling our biological aging process.
This is where IM8’s Daily Ultimate Longevity supplement comes into play.
What is IM8’s Daily Ultimate Longevity Supplement?
IM8 has recently (October 2025) released their new and improved longevity formula to complement their daily essentials, giving you a supplement stack that not only helps you feel more energized and vibrant today, but that is quietly supporting your future self.
The Daily Ultimate Longevity contains 10 key ingredients, all expertly chosen to support the best longevity science available, targeting the 12 markers of aging. Those 12 markers are:
- Genomic instability: Damage building up in your DNA over time, like having too many typos in the cell’s instruction manual.
- Telomere attrition: The protective caps on the ends of your chromosomes (like the plastic tips on shoelaces) getting shorter, which limits how many times cells can divide (as mentioned above).
- Epigenetic alterations: The “software” that tells your genes what to do and when to do it gets buggy and confused as you age, causing the wrong genes to be turned on or off.
- Loss of proteostasis: Your cell’s quality-control system failing, leading to a build-up of damaged, misfolded proteins (like cellular “gunk”).
- Disabled macroautophagy: The cell’s recycling and clean-up system slowing down, leaving old, damaged parts to clog up the machinery.
- Deregulated nutrient-sensing: Your body losing the ability to correctly sense and respond to nutrients (like sugar and fat), leading to metabolic issues.
- Mitochondrial dysfunction: The power plants of your cells (mitochondria) becoming weak and inefficient, resulting in less energy and more harmful byproducts.
- Cellular senescence: Cells that should have died but instead stop dividing and become “zombie cells,” releasing toxic signals that damage healthy neighboring cells.
- Stem cell exhaustion: The body’s repair crew (stem cells) running out of steam, meaning your tissues and organs lose the ability to regenerate and heal.
- Altered intercellular communication: Cells having trouble talking to each other, leading to coordination breakdowns between different tissues and organs.
- Chronic inflammation: A persistent, low-grade level of inflammation throughout the body, like a slow burn, that damages tissues over time.
- Dysbiosis: An unhealthy imbalance in the community of microorganisms (like bacteria) that live in your gut, which affects overall health and immune function.
Backed by some of the brightest minds in longevity science, IM8 has updated its previous formula for maximum potency, now in a powder format that you mix with water.
Their longevity supplement organizes their ingredients into a 5-Complex system:
- Cellular Foundation Builder
- Cellular Protection Activator
- NMN NAD+ Energy Booster
- Metabolic AMPK/SIRT1 Activator
- Cellular Renewal Activator
Now, this can all seem like mumbo-jumbo, word salad, so let me try to break down what each complex, and their respective ingredients does to support longevity.
Complex 1: Cellular Foundation Builder
This complex provides high doses of two critical amino acid-derived compounds, Glycine and Taurine, totaling 5,000 mg.
1. L-Glycine (3,000 mg)
Glycine’s primary function is described as supporting master antioxidant processes and enhancing sleep quality.
Glycine is a precursor to glutathione, the body’s primary endogenous antioxidant, which basically means it helps to protect your cells from oxidative stress. Oxidative stress is an indicator of chronic inflammation, a precursor for more serious health issues.
Additionally, Glycine has been shown to support a restful night sleep, with users reporting deeper and uninterrupted sleep. Getting a good night’s rest is crucial for general wellbeing, as it is an important time for recovery and clearing out the cellular “gunk” that you’ve accumulated throughout the day.
The 3,000 mg dose is considered therapeutic for metabolic health and sleep.
2. Taurine (2,000 mg)
Taurine is another amino-acid and it’s role it to support healthy aging decline and cardiovascular protection.
Research published in the journal Science highlighted that taurine levels decline significantly with age in mammals (like us!), and supplementation increased the lifespan of mice by approximately 10% while improving muscle endurance and strength.
In humans, Taurine has been shown to offer beneficial cardiovascular effects, including blood pressure regulation and happier, healthier blood vessels.
The 2,000 mg dose used in the IM8 supplement aligns with the amount explored in human and animal studies and stands out as the compound with the most direct, highly-cited mammalian lifespan extension evidence amongst all of the ingredients in this longevity supplement.
Complex 2: Cellular Protection Activator
This complex is designed to activate cellular protection and clear your “zombie cells”.
1. Trans-Resveratrol (250 mg)
Resveratrol is lauded for its ability to activate Sirtuin 1 (SIRT1) enzymes, which are key regulators of metabolism and genomic stability, mimicking the effects of caloric restriction.
From the 12 markers of aging, resveratrol targets the changes to our intercellular communication and deregulated nutrient sensing.
Important note: While the 250 mg dose is moderate, its inclusion introduces significant drug interaction risk, as Resveratrol inhibits CYP enzymes, which are critical for drug metabolism in the liver. This may either increase the therapeutic effect or the toxicity of certain prescription drugs. Please speak with your doctor if you are on any prescribed medications.
2. Quercetin (250 mg) and Fisetin (100 mg)
Quercetin is included as a powerful “senolytic “zombie cell killer” (senolytic) and anti-inflammatory agent, while Fisetin is included due to its potent natural senolytic compound.
Senolytics (zombie-cell killers) function by selectively clearing out your zombie cells, which accumulate with age and contribute to inflammation and tissue dysfunction.
Targeting cellular senescence is a major goal of longevity scientists. However, please keep in mind that the research on compounds like these is still relatively new so it isn’t entirely clear what the long-term effects of taking these supplements will do. The research is promising, but it is important to keep an eye on how your body reacts to these types of supplements and to stop taking them if any weird symptoms appear.
Complex 3: NMN NAD+ Energy Booster
The third complex works to improve your cellular energy while also supporting mitochondrial health.
1. Nicotinamide Mononucleotide (NMN 300 mg)
NMN is a direct precursor to Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme essential for hundreds of metabolic processes, including DNA repair and mitochondrial function.
NAD+ levels decline significantly as we get older, which contributes to mitochondrial dysfunction and DNA damage, two of the fundamental hallmarks of aging.
The 300 mg dose is situated within the fixed dosages used in current safety and efficacy human clinical trials for middle-aged and elderly individuals. While some research suggests maximizing benefits may require doses up to 500-750 mg, the 300 mg dose is scientifically relevant and supports the goal of NAD+ restoration.
2. Pyrroloquinoline Quinone (PQQ 10 mg)
PQQ is included for its role in mitochondrial biogenesis (the generation of new mitochodria) and protects those mitochondria from dysfunction. It is essential to the multitude of processes that manage oxidative stress in the body, and it supports the creation of new mitochondria.
The 10 mg dose falls within the 5–20 mg per day range shown in human studies to reduce inflammatory markers and improve signs consistent with enhanced mitochondrial oxidation. The combination of NMN and PQQ is a sophisticated pairing, providing both the necessary energy fuel (NAD+) and support for building and protecting the cellular powerhouses (mitochondria), reflecting a comprehensive approach to mitochondrial dysfunction.
Complex 4: Metabolic AMPK/SIRT1 Activator
Still with me? You’re doing great – we’re almost done! The fourth complex focuses on metabolic regulation and antioxidant defense.
1. Dihydroberberine (100 mg)
Dihydroberberine (DHB) activates key longevity pathways, including AMPK (Adenosine Monophosphate-Activated Protein Kinase) and SIRT1 (sirtuin 1).
Activation of these pathways targets deregulated nutrient sensing (one of the 12 markers of aging mentioned before), improving cellular health and metabolic health.
The selection of DHB over standard Berberine is based on the claim of 5x greater absorption. If this absorption advantage is true, 100 mg of DHB could deliver a potent metabolic effect, equivalent to a much higher, non-absorbable dose of its traditional counterpart.
You may recognize berberine from the health supplement section of your local pharmacy. Berberine has been sold as a weight-management supplement, with the goal of supporting a healthy metabolism and, specifically, balancing blood-sugar levels. With IM8’s Ultimate Daily Longevity supplement, you are getting the more potent version of berberine to maximize your results and more effectively support a healthy metabolism.
2. Astaxanthin (6 mg)
Astaxanthin is an ultra-powerful carotenoid antioxidant intended to provide ultra-powerful antioxidant protection. It helps shield cells from free radical damage, a central mechanism of aging, and may support immune function. The 6 mg dose is within the standard, possibly safe range of 4–18 mg daily used in supplements.
Complex 5: Cellular Renewal Activator (Autophagy)
You made it! The final complex in the 5-Complex system. This complex is dedicated to promoting cellular self-cleaning mechanisms, known as autophagy.
1. Spermidine (3 mg)
Spermidine is a natural polyamine that stimulates macroautophagy, a naturally occuring process where our cells break down and recycle damaged components, thus maintaining protein balance (proteostasis).
If you’ve done any research or reading on intermittent fasting or the ketogenic diet, then you’ll be familiar with autophagy. It’s a necessary process, but one that has been impeded by western lifestyles of overconsumption and chronic stress.
Declining spermidine levels are correlated with age-related deterioration. Preclinical evidence is strong, showing that external supplementation extends lifespan and healthspan across species, including mice.
These 10, well-researched, and highly focused ingredients come together to create an industry-leading longevity supplement. Similar to what they did with their Essentials vs. AG1 comparison table, IM8 has clearly outlined how their longevity supplement compares to other longevity supplements on the market.
How to Get Your Daily Dose of Longevity
This new formulation is now available for purchase on the IM8 website. A single purchase, which includes 30 servings, is CAD $219/USD $149. Not your currency? Their website now allows you to update to your preferred currency so you know what this will cost you.
If you want to purchase this once, and re-stock automatically, you can sign up for a subscription of the Daily Ultimate Longevity for USD $119 per month.
If you’re like me and you’ll be taking advantage of their Daily Essentials and their Daily Longevity, you can get them in the Beckham Stack bundle and save a little money while you’re at it!
A one-time purchase of the Beckham Stack, which gives you 30 servings of the Daily Ultimate Essentials and the Daily Ultimate Longevity, costs USD $261. If you opt for the subscription option, you’ll save a whopping 32%, with each monthly payment coming to USD $179.
When To Take Your Longevity Supplement
The IM8 Daily Ultimate Longevity supplement is a great partner to their daily ultimate essentials because I believe it is best taken at night.
Where their daily ultimate essentials give you natural energy, hydration and nutrients to support brain function, the daily ultimate longevity supplement supports cellular recovery and sleep due to their high dose of glycine.
So you’ll start your day with the refreshing, berry-flavored essentials supplement, and then end your day with their tasty, berry and pomegranate-flavored longevity supplement.
For those of us in our 30’s who are starting to feel the effects of aging, like not being able to eat like you did in your 20’s, or struggling to have the same energy as you used to – this new supplement is a new tool for our health toolkit that will ideally bring back some of that vitality that we may have thought we lost.
I’m really looking forward to getting my hands on this new supplement and even more excited to share with you how it makes me feel and the results I experience! To get caught up on my experience with IM8’s Daily Ultimate Essentials, check out the previous articles below.
Riley Pearce 